Tuesday, 9 December 2014

THE IMPORTANCE OF SYMMETRY OPERATIONS IN THE UNDERSTANDING OF CHEMICAL PROPERTIES AND CHEMICAL REACTIONS

1.1       INTRODUCTION
We will already be familiar with the concept of symmetry in an everyday sense. If we say something is ‘symmetrical’, we usually mean it has mirror symmetry, or ‘left-right’ symmetry, and would look the same if viewed in a mirror. Symmetry is also very important in chemistry. Some molecules are clearly ‘more symmetrical’ than others, but what consequences does this have, if any? The aim of this course is to provide a systematic treatment of symmetry in chemical systems within the mathematical framework known as group theory. Once we have classified the symmetry of a molecule, group theory provides a powerful set of tools that provide us with considerable insight into many of its chemical and physical properties.
Symmetry (from Greek συμμετρία symmetria "agreement in dimensions, due proportion, arrangement") in everyday language refers to a sense of harmonious and beautiful proportion and balance. In mathematics, "symmetry" has a more precise definition, that an object is invariant to a transformation, such as reflection but including other transforms too. Although these two meanings of "symmetry" can sometimes be told apart, they are related, so they are here discussed together.
Mathematical symmetry may be observed with respect to the passage of time; as a spatial relationship; through geometric transformations such as scalingreflection, and rotation; through other kinds of functional transformations; and as an aspect of abstract objectstheoretic models, languagemusic and even knowledge itself.
This article describes symmetry from four perspectives: in geometry, the most familiar type of symmetry for many people; more generally, in mathematics as a whole; as it relates to science and nature; and in the arts, covering architectureart and music.
The opposite of symmetry is asymmetry.
In chemistry, a property manifested in the geometrical configuration of molecules and affecting the physical and chemical properties of molecules in the isolated state, in an external field, and in interactions with other atoms and molecules.
Most simple molecules possess such elements of spatial symmetry in the equilibrium configuration as axes of symmetry and symmetry planes. Thus, a molecule of ammonia (NH3) possesses the symmetry of a regular triangular pyramid, while a molecule of methane (CH4) possesses the symmetry of a tetrahedron. In complex molecules, symmetry of the equilibrium configuration of the molecule as a whole is usually absent although to a great extent the symmetry of the individual molecular fragments (local symmetry) is preserved. The most complete description of symmetry of both equilibrium and non-equilibrium configurations of molecules is obtained from the concept of dynamic symmetry groups, that is, groups that include not only operations of spatial symmetry of the nuclear configuration but also operations involving the transposition of identical nuclei in various configurations. For example, the dynamic symmetry group for the NH3 molecule also includes the operation of inversion of this molecule: the transfer of the N atom from one side of the plane formed by the H atoms to the other.
The symmetry of the equilibrium configuration of the nuclei in a molecule determines the symmetry of the wave functions for various states of the molecule. This relationship permits a classification of states according to symmetry types. The transition between two states is related to the absorption or emission of light; depending on the symmetry types of the states, the transition either will be seen in the molecular spectrum or else will be forbidden, in which case the line or band corresponding to this transition will be absent in the spectrum. The symmetry types of states between which transitions are possible affect both the intensity and the polarization of spectral lines and bands. For example, in homo-nuclear diatomic molecules, transitions between electronic states of identical parity, the electronic wave functions of which behave identically upon inversion, are forbidden and do not appear in the spectra. Also, in molecules of benzene and analogous compounds, transitions between non degenerate electronic states of the same symmetry type are also forbidden. The rules for selection according to symmetry are complemented for transitions between different states by selection rules related to the spin of these states.
In molecules with paramagnetic centres, the symmetry of the environment of these centres leads to a given type of anisotropy of the g-factor (Landé splitting factor); this anisotropy affects the structure of the electron paramagnetic resonance spectrum. In molecules with nuclei possessing nonzero spin, the symmetry of the individual local fragments leads to a distinct type of splitting of the energy states with different projections of nuclear spin; this splitting affects the structure of nuclear magnetic resonance spectrum.
In the approximate methods of quantum chemistry, which make use of the concept of molecular orbitals, classification according to symmetry is possible not only for the wave function of the molecule as a whole but also for the individual orbitals. If the equilibrium configuration of a molecule has a symmetry plane containing nuclei, all the orbitals of the molecule will fall into one of two classes, being either symmetrical (σ)or anti-symmetrical (π) relative to the operation of reflection in this plane. Molecules in which m orbitals are the highest (with respect to energy), occupied orbitals form specific classes of unsaturated and conjugated compounds with characteristic properties. Knowledge of the local symmetry of the individual fragments of a molecule and of the molecular orbitals localized on these fragments permits an evaluation of which fragments will more readily undergo excitation and will be more strongly altered in the course of chemical transformations, for example  in photochemical reactions.
Symmetry concepts have great importance in the theoretical analysis of the structure, properties, and behaviour in various reactions of complex compounds. Crystal field theory and ligand field theory postulate a mutual arrangement of the occupied and vacant orbitals of a complex compound on the basis of data on the compound’s symmetry. The theories also postulate the nature and degree of the splitting of energy levels upon a change in the symmetry of the ligand field. Knowledge of only the symmetry of a complex very often permits a qualitative evaluation of the complex’s properties.
In 1965, R. Woodward and R. Hoffmann proposed the principle of conservation of orbital symmetry in chemical reactions. The principle has been confirmed by experiment and has had a great impact on the development of the branch of organic chemistry dealing with the preparation of substances. Known as the Woodward-Hoffmann rule, it states that the individual steps of a chemical reaction proceed with the conservation of the symmetry of the molecular orbitals, or orbital symmetry. The greater the violation of orbital symmetry in a particular step, the more difficult it is for the reaction to proceed.
Consideration of the symmetry of molecules is important in selecting the materials used in producing chemical lasers and molecular rectifiers, building models of organic superconductors, and analysing carcinogenic and pharmacologically active substances.



2.1       IMPORTANCE OF SYMMETRY OPERATIONS IN CHEMICAL PROPERTIES AND CHEMICAL REACTIONS
Symmetry is important to chemistry because it undergirds essentially all specific interactions between molecules in nature (i.e., via the interaction of natural and human-made chiral molecules with inherently chiral biological systems). The control of the symmetry of molecules produced in modern chemical synthesis contributes to the ability of scientists to offer therapeutic interventions with minimal side effects. A rigorous understanding of symmetry explains fundamental observations in quantum chemistry, and in the applied areas of spectroscopy and crystallography. The theory and application of symmetry to these areas of physical science draws heavily on the mathematical area of group theory. This is the reason why symmetry operations and symmetry elements in a molecule are important to the inorganic chemistry.

2.1.1    Constructing Molecular and Hybrid Orbitals
In chemistry, a molecular orbital (or MO) is a mathematical function describing the wave-like behaviour of an electron in a molecule. This function can be used to calculate chemical and physical properties such as the probability of finding an electron in any specific region. The term orbital was introduced by Robert S. Mulliken in 1932 as an abbreviation for one-electron orbital wave function.[1] At an elementary level it is used to describe the region of space in which the function has a significant amplitude. Molecular orbitals are usually constructed by combining atomic orbitals or hybrid orbitals from each atom of the molecule, or other molecular orbitals from groups of atoms. They can be quantitatively calculated using the Hartree–Fock or self-consistent field (SCF) methods.
A molecular orbital (MO) can be used to represent the regions in a molecule where an electron occupying that orbital is likely to be found. Molecular orbitals are obtained from the combination of atomic orbitals, which predict the location of an electron in an atom. A molecular orbital can specify the electron configuration of a molecule: the spatial distribution and energy of one (or one pair of) electron(s). Most commonly an MO is represented as a linear combination of atomic orbitals (the LCAO-MO method), especially in qualitative or very approximate usage. They are invaluable in providing a simple model of bonding in molecules, understood through molecular orbital theory. Most present-day methods in computational chemistry begin by calculating the MOs of the system. A molecular orbital describes the behaviour of one electron in the electric field generated by the nuclei and some average distribution of the other electrons. In the case of two electrons occupying the same orbital, the Pauli principle demands that they have opposite spin. Necessarily this is an approximation, and highly accurate descriptions of the molecular electronic wave function do not have orbitals.
Molecular orbitals arise from allowed interactions between atomic orbitals, which are allowed if the symmetries (determined from group theory) of the atomic orbitals are compatible with each other. Efficiency of atomic orbital interactions is determined from the overlap (a measure of how well two orbitals constructively interact with one another) between two atomic orbitals, which is significant if the atomic orbitals are close in energy. Finally, the number of molecular orbitals that form must equal the number of atomic orbitals in the atoms being combined to form the molecule.
Molecular orbitals were first introduced by Friedrich Hund and Robert S. Mulliken in 1927 and 1928. The linear combination of atomic orbitals or "LCAO" approximation for molecular orbitals was introduced in 1929 by Sir John Lennard-Jones.[8] His ground-breaking paper showed how to derive the electronic structure of the fluorine and oxygen molecules from quantum principles. This qualitative approach to molecular orbital theory is part of the start of modern quantum chemistry. Linear combinations of atomic orbitals (LCAO) can be used to estimate the molecular orbitals that are formed upon bonding between the molecule's constituent atoms. Similar to an atomic orbital, a Schrödinger equation, which describes the behaviour of an electron, can be constructed for a molecular orbital as well. Linear combinations of atomic orbitals, or the sums and differences of the atomic wave functions, provide approximate solutions to the Hartree–Fock equations which correspond to the independent-particle approximation of the molecular Schrödinger equation. As the two atoms become closer together, their atomic orbitals overlap to produce areas of high electron density, and, as a consequence, molecular orbitals are formed between the two atoms. The atoms are held together by the electrostatic attraction between the positively charged nuclei and the negatively charged electrons occupying bonding molecular orbitals.
A MO with σ symmetry results from the interaction of either two atomic s-orbitals or two atomic pz-orbitals. An MO will have σ-symmetry if the orbital is symmetrical with respect to the axis joining the two nuclear centres, the inter-nuclear axis. This means that rotation of the MO about the inter-nuclear axis does not result in a phase change. A σ* orbital, sigma anti-bonding orbital, also maintains the same phase when rotated about the inter-nuclear axis. The σ* orbital has a nodal plane that is between the nuclei and perpendicular to the inter-nuclear axis.

2.1.2    Interpreting  Spectroscopic
2.1.2.1 Vibrational Spectroscopy
Infrared (IR) and Raman spectroscopies are branches of vibrational spectroscopy and the former technique is much the more widely available of the two in student teaching laboratories.  Vibrational spectroscopy is concerned with the observation of the degrees of vibrational freedom, the number  of which can be determined as follows. the motion of the molecule containing n atoms can conveniently be described in terms of three Cartesian axes, the molecule has 3n degrees of freedom which together describe the translational, vibrational and rotational motions of the molecule.

2.1.2.2 Raman Spectroscopy
Chandrasekhara V. Raman was awarded the 1930 Nobel Prize in Physics ‘for his work on the scattering of light and for the discovery of the effect named after him’. When radiation usually from the laser of a particular frequency, v0, falls on a vibrating molecule, most of the radiation is scattered without change in frequency. This is called Rayleigh scattering. One of the advantages of Raman spectroscopy is that is extends to lower wave numbers than routine laboratory IR spectroscopy, thereby permitting the observation of, for example, metal-ligand vibrational modes. A disadvantage of the Raman effect is its insentivity since only a tiny percentage of the scattered radiation undergoes Raman scattering. one way of overcoming this is to use a Fourier transform (FT technique). A second way, suitable only for coloured compound, is used to resonance Raman spectroscopy. This technique realise on using laser excitation wavelength that co-inside with wavelengths of absorbtion in the electronic spectrum of a compound. This leads to resonance enhancement and increase in the intensity of lines in the Raman spectrum. Resonance Raman spectroscopy is now used extensively for the investigation of coloured d-block metal complexes and for probing the active metals side in metalloproteins.

2.1.2.3 Predict Whether a Given Molecule is Chiral
One example of symmetry in chemistry that you will already have come across is found in the isomeric pairs of molecules called enantiomers. Enantiomers are non-superimposable mirror images of each other, and one consequence of this symmetrical relationship is that they rotate the plane of polarized light passing through them in opposite directions. Such molecules are said to be chiral, meaning that they cannot be superimposed on their mirror image. Formally, the symmetry element that precludes a molecule from being chiral is a rotation-reflection axis. Chiral molecule can rotate the plane of plane-polarized light. This property is known as optical activity and the two mirror images are known as optical isomers or enantiomers.
The importance of chirality is clearly seen in, for example, dramatic differences in the activities of different enantiomers of chiral drugs. A helical chain is easy to recognize, but it is not always search a fasile task to identify a chiral compound by attempting to convince oneself that it is, or is not, non-superposable on its mirror image. symmetry consideration come to our aid; a chiral molecular species must lack an improper (Sn) axis of symmetry.
Another commonly used criterion of an inversion centre, i, and plane of symmetry, σ. However, both of this properties are compatible with the criterion given above, since we can rewrite the symmetry operation i and σ in terms of the improper rotation S2 and S1 respectively.

3.1       SUMMARY

Symmetry is a property of molecules having more than one atom of the same kind, with equal bond lengths and/or bond angles. As like the high symmetry of the SF6 molecule arises from the six equal S-F bonds disposed at angles of 90° to each other. In order to build the notion more precise we use the idea of a symmetry operation. For example rotating SF6 by 90° about an appropriate axis, it appears indistinguishable after the rotation. The axis concerned is known as the symmetry element. Rotations which do not leave the molecule looking the similar are not symmetry operations.


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